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Description

GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids (Mannervik, 1985

202 , e0014620 (2020)

According to estimates, almost 80% of cobalamin present in body is in the form of methylcobalamin

Additionally, any newly identified drug lead has to pass the acid test of pre-clinical efficacy, safety, and compatibility with the existing first-line and second-line drugs